Response to Therapy Following Retreatment of Serofast Early Syphilis Patients With Benzathine Penicillin

Serological response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin.

Background Some syphilitic patients remain in a serologically positive state after the recommended therapy. Although we often retreat patients in clinical practice, the optimal treatment protocol remains uncertain due to the paucity of data regarding serological response to retreatment and long-term outcomes. Methods We examined rapid plasma reagin serological test results of 70 serofast earl...

Retreatment of Serofast Early Syphilis Patients With Benzathine Penicillin

Arlene C. Seña, Mark Wolff, Frieda Behets, Kathleen Van Damme, David H. Martin, Peter Leone, Linda McNeil, and Edward W. Hook Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill; EMMES Corporation, Rockville, Maryland; Department of Epidemiology, University of North Carolina at Madagascar, Antananarivo; Department of Medicine, Louisiana State Uni...

Jarisch-Herxheimer reaction among HIV-positive patients with early syphilis: azithromycin versus benzathine penicillin G therapy

INTRODUCTION The Jarisch-Herxheimer reaction, a febrile inflammatory reaction that often occurs after the first dose of chemotherapy in spirochetal diseases, may result in deleterious effects to patients with neurosyphilis and to pregnant women. A single 2-g oral dose of azithromycin is an alternative treatment to benzathine penicillin G for early syphilis in areas with low macrolide resistance...

Early syphilis: serological treatment response to doxycycline/tetracycline versus benzathine penicillin.

INTRODUCTION Benzathine penicillin G is the treatment of choice for syphilis, but doxycycline and tetracycline are effective second-line treatments. The objective of this study was to assess the serological response to treatment for early syphilis with benzathine penicillin compared with doxycycline or tetracycline. METHODOLOGY We examined rapid plasma regain (RPR) serological test results of...

Penicillin therapy of early syphilis.